Bilateral salpingo‐oophorectomy (BSO) is a risk management approach with strong evidence of mortality reduction for women with germline mutations in the tumor suppressor genes BRCA1 and BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry BRCA1/2 mutations. The objective of the UPTAKE study was to explore rates and predictors of risk‐reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious BRCA1/2 mutation. We recruited 100 Latina women with deleterious BRCA1/2 mutations from community hospitals, academic health systems, community, and advocacy organizations. Women completed interviews in Spanish or English. We obtained copies of genetic test reports for participants who provided signed medical release. After performing threefold cross‐validation LASSO for variable selection, we used multiple logistic regression to identify demographic and clinical predictors of BSO. Among 100 participants, 68 had undergone BSO at the time of interview. Of these 68, 35 were US‐born (61% of all US‐born participants) and 33 were not (77% of the non‐US‐born participants). Among Latinas with BRCA1/2 mutations, older age (p = 0.004), personal history of breast cancer (p = 0.003), higher income (p = 0.002), and not having a full‐time job (p = 0.027) were identified as variables significantly associated with uptake of BSO. Results suggest a high rate of uptake of risk‐reducing BSO among a sample of Latinas with BRCA1/2 mutations living in the US. We document factors associated with BSO uptake in a diverse sample of women. Relevant to genetic counseling, our findings identify possible targets for supporting Latinas’ decision‐making about BSO following receipt of a positive BRCA1/2 test.

中文翻译：

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拉丁裔中的 BRCA1/2 突变和降低风险的双侧输卵管卵巢切除术：UPTAKE 研究

双侧输卵管卵巢切除术 (BSO) 是一种风险管理方法，有强有力的证据表明肿瘤抑制基因BRCA1和BRCA2 ( BRCA1/2 ) 发生种系突变的女性死亡率降低。迄今为止，很少有研究评估携带BRCA1/2突变的来自不同种族和民族背景的女性对 BSO 的吸收情况。UPTAKE 研究的目的是探索具有有害BRCA1/2突变的受乳腺癌影响和未受乳腺癌影响的拉丁裔人群降低 BSO 风险的比率和预测因子。我们招募了 100 名患有有害BRCA1/2的拉丁裔女性来自社区医院、学术卫生系统、社区和宣传组织的突变。女性用西班牙语或英语完成了采访。我们为提供签名医疗证明的参与者获得了基因检测报告的副本。在对变量选择进行三重交叉验证 LASSO 后，我们使用多元逻辑回归来确定 BSO 的人口统计学和临床​​预测因子。在 100 名参与者中，68 人在采访时接受了 BSO。在这 68 人中，35 人是美国出生的（占所有美国出生参与者的 61%），33 人不是（占非美国出生参与者的 77%）。在具有BRCA1/2的拉丁裔中突变、年龄较大 (p = 0.004)、乳腺癌个人史 (p = 0.003)、高收入 (p = 0.002) 和没有全职工作 (p = 0.027) 被确定为与摄取显着相关的变量BSO 的。结果表明，在美国生活的具有BRCA1/2突变的拉丁裔样本中，降低风险的 BSO 摄入率很高。我们记录了不同女性样本中与 BSO 吸收相关的因素。与遗传咨询相关，我们的研究结果确定了支持拉丁裔在收到BRCA1/2检测呈阳性后就 BSO 做出决策的可能目标。