Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers,Human Brain Mapping

当前位置： X-MOL 学术 › Hum. Brain Mapp. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-03 , DOI: 10.1002/hbm.25193
Linde de Wandel _{1,

2} , Matias M Pulopulos _{3,

4} , Vytautas Labanauskas _{1,

2} , Sara de Witte _{1,

2} , Marie-Anne Vanderhasselt _{1,

2,

3} , Chris Baeken _{1,

2,

5,

6}

Affiliation

Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stress‐related mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of its effectiveness. Clinical research suggests that resting‐state functional connectivity (rsFC) between the DLPFC and the anterior cingulate cortex (ACC) can predict iTBS treatment response in depression. The present study aimed to investigate whether rsFC between the left DLPFC and ACC subregions could predict the degree to which the stress system is affected by iTBS. After assessment of baseline resting‐state fMRI data, 34 healthy female participants performed the Trier Social Stress Test on two separate days, each followed by active or sham iTBS over the left DLPFC. To evaluate iTBS effects on the stress‐system, salivary cortisol was measured throughout the procedure. Our results showed that a stronger negative correlation between the left DLPFC and the caudal ACC was linked to a larger attenuation of stress‐system sensitivity during active, but not during sham iTBS. In conclusion, based on individual rsFC between left DLPFC and caudal ACC, iTBS could be optimized to more effectively attenuate deregulation of the stress system.

中文翻译：

个体静息状态前额突功能连接可预测健康女性志愿者对压力的间歇性 theta 爆发刺激反应

传递到背外侧前额叶皮层 (DLPFC) 的间歇性 theta 爆发刺激 (iTBS) 已被研究作为一种有前途的治疗压力和压力相关精神障碍（如重度抑郁症）的方法，但反应性的巨大个体差异需要进一步探索和优化其有效性. 临床研究表明，DLPFC 和前扣带回皮层 (ACC) 之间的静息状态功能连接 (rsFC) 可以预测抑郁症的 iTBS 治疗反应。本研究旨在调查左侧 DLPFC 和 ACC 亚区之间的 rsFC 是否可以预测应力系统受 iTBS 影响的程度。在评估基线静息状态 fMRI 数据后，34 名健康女性参与者在两天内进行了特里尔社会压力测试，每个紧接着是左侧 DLPFC 上的活动或假 iTBS。为了评估 iTBS 对压力系统的影响，在整个过程中测量了唾液皮质醇。我们的结果表明，左侧 DLPFC 和尾部 ACC 之间更强的负相关与活动期间压力系统敏感性的更大衰减有关，但在假 iTBS 期间则不然。总之，基于左侧 DLPFC 和尾部 ACC 之间的个体 rsFC，可以优化 iTBS 以更有效地减轻压力系统的失调。但不是在假 iTBS 期间。总之，基于左侧 DLPFC 和尾部 ACC 之间的个体 rsFC，可以优化 iTBS 以更有效地减轻压力系统的失调。但不是在假 iTBS 期间。总之，基于左侧 DLPFC 和尾部 ACC 之间的个体 rsFC，可以优化 iTBS 以更有效地减轻压力系统的失调。

更新日期：2020-11-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11