Protein corona: Dr. Jekyll and Mr. Hyde of nanomedicine,Biotechnology and Applied Biochemistry

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Protein corona: Dr. Jekyll and Mr. Hyde of nanomedicine
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-10-02 , DOI: 10.1002/bab.2035
Elisa Fasoli ₁

Affiliation

Nanomedicine is an interdisciplinary field of research, comprising science, engineering, and medicine. Many are the clinical applications of nanomedicine, such as molecular imaging, medical diagnostics, targeted therapy, and image-guided surgery. Despite major advances during the past 20 years, many efforts must be done to understand the complex behavior of nanoparticles (NPs) under physiological conditions, the kinetic and thermodynamic principles, involved in the rational design of NP. Once administrated in physiological environment, NPs interact with biomolecules and they are surrounded by protein corona (PC) or biocorona. PC can trigger an immune response, affecting NPs toxicity and targeting capacity. This review aims to provide a detailed description of biocorona and of parameters that are able to control PC formation and composition. Indeed, the review provides an overview about the role of PC in the modulation of both cytotoxicity and immune response as well as in the control of targeting capacity.

中文翻译：

蛋白质电晕：纳米医学的 Jekyll 博士和 Hyde 先生

纳米医学是一个跨学科的研究领域，包括科学、工程和医学。许多是纳米医学的临床应用，例如分子成像、医学诊断、靶向治疗和图像引导手术。尽管在过去的 20 年中取得了重大进展，但必须做许多努力来了解纳米粒子 (NPs) 在生理条件下的复杂行为、动力学和热力学原理，以及纳米粒子的合理设计。一旦在生理环境中给药，NPs 与生物分子相互作用，它们被蛋白质电晕 (PC) 或生物电晕包围。PC 可以触发免疫反应，影响 NPs 的毒性和靶向能力。本综述旨在提供对生物电晕和能够控制 PC 形成和组成的参数的详细描述。的确，

更新日期：2020-10-02

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