Abstract We summarize recent advances in application of MOFs as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine. A holistic perspective is adopted to produce a comprehensive, critical and readable document useful to a broad community in chemistry, material science, medical fields etc. None of the previous articles adopted a holistic approach focusing on a specific disease or area, such as cancer. MOFs have a tremendous potential in cancer diagnostics and treatment. Although a new field, the amount of literature and data accumulated in this area is vast, quickly growing and requires some systematization and processing. We propose a broad overview of MOF-related literature in the treatment and diagnosis of cancer. In our study, we set: (i) to consolidate the most important and up to date information from the field of MOFs applications in medicine, particularly in anticancer therapy; and to reflect these developments in one, comprehensive study, (ii) to highlight new and emerging topics in the field, (iii) to tabulate the large number of the application examples and case studies to make the information more accessible and easy to follow, (iv) and finally, to broadly reflect on the potential of MOFs in application to cancer treatment, including the existing challenges and emerging opportunities.

中文翻译：

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MOF 材料在癌症生物医学中作为治疗剂、药物载体、显像剂和生物传感器：最新进展和前景

摘要 我们总结了 MOF 作为治疗剂、药物载体、显像剂和生物传感器在癌症生物医学中的应用的最新进展。采用整体观点来制作对化学、材料科学、医学领域等广泛社区有用的全面、批判性和可读性的文件。以前的文章都没有采用专注于特定疾病或领域（例如癌症）的整体方法。MOF 在癌症诊断和治疗方面具有巨大的潜力。虽然是一个新领域，但该领域积累的文献和数据量巨大，增长迅速，需要一些系统化和处理。我们建议对癌症治疗和诊断中与 MOF 相关的文献进行广泛的概述。在我们的研究中，我们设置：(i) 整合 MOF 在医学领域，特别是在抗癌治疗领域的应用领域中最重要和最新的信息；并在一项综合研究中反映这些发展，(ii) 突出该领域的新兴主题，(iii) 将大量应用示例和案例研究制成表格，以使信息更易于获取和理解， (iv) 最后，广泛反思 MOFs 在癌症治疗中的应用潜力，包括现有的挑战和新出现的机遇。