We investigated the effect of a high-fat diet on body metabolism and ventral prostate morphology in 4-months-old offspring. The mother was fed with a control (C) or a high-fat (HF) diet during gestation and lactation. At weaning, the offspring diet remained the same (C/C, n = 8; HF/HF, n = 8) or it was switched (C/HF, n = 8; HF/C, n = 9). Biometry, blood pressure (BP), glucose, lipid metabolism and ventral prostate were evaluated. Triacylglycerol of HF/C increased, and the C/HF group had decreased HDL-c levels (P = 0.0005 and P = 0.0100, respectively). All groups on the HF diet presented hyperglycemia (P = 0.0064). Serum testosterone diminished in the C/HF group (P = 0.0218). The HF diet, regardless of the period, reduced prostatic acinar area (P < 0.0001). The epithelium height was smaller in HF/C and HF/HF groups compared with C/C and C/HF (P < 0.0001), and the volume density of epithelium was lower in HF/C group compared with the C/C and C/HF (P = 0.0024). The volume density of smooth muscle cells diminished in C/HF and HF/C (P = 0.0013), and the volume density of connective tissue was reduced in HF/C and HF/HF (P < 0.0001). High-fat diet intake during prenatal and postnatal life leads to prostatic atrophy, which may impair prostate secretory activity and contractility, and thus disturb reproductive function in adulthood.

中文翻译：

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高脂饮食对胎儿编程促进成年Wistar白化大鼠前列腺下降

我们研究了高脂肪饮食对 4 个月大的后代的身体代谢和腹侧前列腺形态的影响。母亲在妊娠和哺乳期间喂食对照 (C) 或高脂肪 (HF) 饮食。断奶时，后代饮食保持不变（C/C，n = 8；HF/HF，n = 8）或改变（C/HF，n = 8；HF/C，n = 9）。评估了生物测定、血压 (BP)、葡萄糖、脂质代谢和腹侧前列腺。HF/C 的三酰甘油增加，而 C/HF 组的 HDL-c 水平降低（分别为 P = 0.0005 和 P = 0.0100）。HF 饮食的所有组都出现高血糖症（P = 0.0064）。C/HF 组的血清睾酮减少 (P = 0.0218)。无论时间长短，HF 饮食都会减少前列腺腺泡面积（P < 0.0001）。HF/C和HF/HF组上皮高度低于C/C和C/HF（P < 0.0001），HF/C组上皮体积密度低于C/C和C /HF (P = 0.0024)。平滑肌细胞的体积密度在 C/HF 和 HF/C 中降低（P = 0.0013），结缔组织的体积密度在 HF/C 和 HF/HF 中降低（P < 0.0001）。产前和产后摄入高脂肪饮食会导致前列腺萎缩，这可能会损害前列腺的分泌活动和收缩力，从而干扰成年后的生殖功能。HF/C 和 HF/HF 中结缔组织的体积密度降低（P < 0.0001）。产前和产后摄入高脂肪饮食会导致前列腺萎缩，这可能会损害前列腺的分泌活动和收缩力，从而干扰成年后的生殖功能。HF/C 和 HF/HF 中结缔组织的体积密度降低（P < 0.0001）。产前和产后摄入高脂肪饮食会导致前列腺萎缩，这可能会损害前列腺的分泌活动和收缩力，从而干扰成年后的生殖功能。