Healthy brain tissue pulsates with the cardiac cycle, but whether brain tissue pulsations (BTPs) are impaired by tissue ischemia due to ischemic stroke is currently unclear. This study is the first to explore the clinical potential of measuring BTPs using ultrasound in acute ischemic stroke patients. BTPs were measured in 24 healthy volunteers (aged 52-82 years) and 14 acute ischemic stroke patients (aged 51-86 years) using a novel Transcranial Tissue Doppler (TCTD) method. Measurements were quick to perform and were well tolerated by all subjects. A mixed-methods approach was used for blinded analysis of recordings. This identified qualitative disruption of BTPs in acute stroke patients, which were used to create an analysis checklist. Blinded BTP analysis by novices using the checklist resulted in high sensitivity but low specificity for stroke detection. Quantitative analysis also identified differences between stroke and healthy participants, including weaker BTPs in stroke patients. This first study reporting BTP characteristics in acute ischemic stroke revealed weaker brain tissue pulsations and waveform disruption in acute stroke patients. However, further clinical evaluation using a larger sample size is required to confirm these findings and to explore whether TCTD monitoring might be beneficial for clinical neuromonitoring.

中文翻译：

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使用脑组织搏动诊断急性缺血性中风

健康的脑组织随着心动周期而搏动，但脑组织搏动 (BTP) 是否会因缺血性中风引起的组织缺血而受损，目前尚不清楚。本研究首次探索了在急性缺血性中风患者中使用超声测量 BTP 的临床潜力。使用新型经颅组织多普勒 (TCTD) 方法测量了 24 名健康志愿者（52-82 岁）和 14 名急性缺血性中风患者（51-86 岁）的 BTP。测量快速执行并且所有受试者都能很好地耐受。混合方法用于对录音进行盲法分析。这确定了急性中风患者中 BTP 的定性破坏，用于创建分析清单。新手使用检查表进行盲法 BTP 分析导致中风检测的灵敏度高但特异性低。定量分析还确定了中风和健康参与者之间的差异，包括中风患者的 BTP 较弱。第一项报告急性缺血性中风的 BTP 特征的研究揭示了急性中风患者的脑组织搏动较弱和波形中断。然而，需要使用更大样本量的进一步临床评估来证实这些发现，并探索 TCTD 监测是否可能有益于临床神经监测。第一项报告急性缺血性中风的 BTP 特征的研究揭示了急性中风患者的脑组织搏动较弱和波形中断。然而，需要使用更大样本量的进一步临床评估来证实这些发现，并探索 TCTD 监测是否可能有益于临床神经监测。第一项报告急性缺血性中风的 BTP 特征的研究揭示了急性中风患者的脑组织搏动较弱和波形中断。然而，需要使用更大样本量的进一步临床评估来证实这些发现，并探索 TCTD 监测是否可能有益于临床神经监测。