Parkinson’s disease (PD) is becoming a major public-health issue in an aging population. Available approaches to treat advanced PD still have limitations; new therapies are needed. The non-invasive brain stimulation (NIBS) may offer a complementary approach to treat advanced PD by personalized stimulation. Although NIBS is not as effective as the gold-standard levodopa, recent randomized controlled trials show promising outcomes in the treatment of PD symptoms. Nevertheless, only a few NIBS-stimulation paradigms have shown to improve PD’s symptoms. Current clinical recommendations based on the level of evidence are reported in Table 1 through Table 3. Furthermore, novel technological advances hold promise and may soon enable the non-invasive stimulation of deeper brain structures for longer periods.

帕金森氏病（PD）成为人口老龄化的主要公共卫生问题。现有的治疗晚期PD的方法仍然存在局限性。需要新的疗法。非侵入性脑刺激（NIBS）可以通过个性化刺激提供补充方法来治疗晚期PD。尽管NIBS不如金标准左旋多巴有效，但最近的随机对照试验显示，在PD症状的治疗中有希望的结果。然而，只有少数NIBS刺激范例可以改善PD的症状。表1至表3报告了基于证据水平的当前临床建议。此外，新技术的发展有望实现，并且可能会在较长时期内以无创方式刺激更深的大脑结构。