A 3.5-year-old Holstein cow presented with a 2-week history of weakness, ataxia and difficulty in rising, followed by recumbency. At necropsy, a 3 × 2.5 cm tumour mass was found in the subdural area of the left parietal lobe of the cerebrum. Histopathology revealed the tumour to be a variant of secretory meningeal tumour. Immunohistochemically, all of the neoplastic cells expressed vimentin and some were immunopositive for cytokeratin. There were variably sized, scattered pseudocysts containing eosinophilic material that stained positively with Alcian blue and periodic acid–Schiff stains. The marginal zone of the tumour exhibited regressive change characterized by lymphocytic infiltration and extensive fibrotic areas enclosing large numbers of tumour cell nests in which most tumour cells were apoptotic. This tumour was considered to be a secretory variant of cerebral meningioma with partial spontaneous regression.

一头 3.5 岁的荷斯坦奶牛出现 2 周虚弱、共济失调和起身困难，随后卧床。尸检时，在大脑左顶叶的硬膜下区域发现了一个 3 × 2.5 cm 的肿瘤块。组织病理学显示该肿瘤是分泌性脑膜肿瘤的一种变体。免疫组织化学上，所有肿瘤细胞都表达波形蛋白，有些细胞角蛋白呈免疫阳性。有大小不一、散在的假性囊肿，含有嗜酸性物质，用阿尔辛蓝和高碘酸-希夫染色阳性。肿瘤的边缘区表现出退行性变化，其特征是淋巴细胞浸润和广泛的纤维化区域，其中包含大量肿瘤细胞巢，其中大多数肿瘤细胞凋亡。