The present study was assessed to determine the in vivo toxic effects of a cationic surfactant, cetylpyridinium chloride (CPC), and an anionic surfactant, sodium dodecyl sulfate (SDS) in terms of oxidative stress biomarkers in benthic oligochaete worm Tubifex tubifex for 14 days. The investigation demonstrated that sublethal concentrations of CPC (0.0213, and 0.0639 mg L⁻¹) and SDS (1.094 and 3.092 mg L⁻¹)induced paramount alterations in the oxidative stress enzymes in Tubifex tubifex. Superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH), and glutathione peroxidase (GPx) exhibited an initial notable increase in their activities in the surfactants exposed worms at 1d and 7d of exposure period followed by consequential reduction at 14d exposure period with respect to control, while catalase (CAT) and malondialdehyde (MDA) activities markedly incremented gradually throughout the exposure periods. Through the construction of the correlation matrix and integrated biomarker response (IBR), the effects of CPC and SDS on Tubifex tubifex were distinguished. These results indicate that exposure to these cationic and anionic surfactants modulates the levels of oxidative stress enzymes in Tubifex tubifex.

评估本研究以确定在底栖低聚蠕虫Tubifextubifex中氧化应激生物标志物方面，阳离子表面活性剂十六烷基氯化吡啶鎓（CPC）和阴离子表面活性剂十二烷基硫酸钠（SDS）在体内的毒性作用，持续14天。调查表明，CPC的亚致死浓度（0.0213和0.0639毫克的L ^-1）和SDS（​​1.094和3.092毫克的L ^-1）诱导的最重要的改变在氧化应激的酶水丝蚓水丝蚓。超氧化物歧化酶（SOD），谷胱甘肽S-转移酶（GST），还原型谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GPx）在暴露期的1d和7d暴露于表面活性剂的蠕虫中，其活性显着增加，随后依次减少与对照组相比，在14d暴露期，过氧化氢酶（CAT）和丙二醛（MDA）活性在整个暴露期逐渐增加。通过建立相关矩阵和整合生物标志物反应（IBR），区分了CPC和SDS对塔比菲管的影响。这些结果表明，暴露于这些阳离子和阴离子表面活性剂可以调节Tubifextubifex中的氧化应激酶水平。