The exposure to metals is known to generate oxidative stress in living organisms, which can result in the induction of protective antioxidant defences, both enzymatic and non-enzymatic. This work aims to obtain new data on the existing links among several non-enzymatic components of the antioxidant system, that are physiologically related to both metal sequestration and defense against metal-induced oxidative stress, using the blue mussels (Mytilus galloprovincialis) as a model organism. Specimens of this marine bivalve were experimentally exposed to cadmium (Cd), used as oxidative stress inducer. Cd, metallothionein (MT), glutathione (GSH), malondialdehyde (MDA) contents, and glutathione reductase (GR) activity in gills and in digestive glands were assessed at 0, 12, 24, 48, 72 and 96 h. The obtained results provide new data about the relationships among the non-enzymatic antioxidant cellular components considered in this study. These constitute the prompt physiological responses to the oxidative stress in blue mussels exposed to Cd in controlled laboratory conditions.

已知暴露于金属会在活生物体中产生氧化应激，这可导致诱导酶性和非酶性的保护性抗氧化防御。这项工作旨在利用蓝贻贝（Mytilus galloprovincialis），获得有关抗氧化剂系统的几种非酶组分之间现有联系的新数据，这些组分与金属螯合和防御金属诱导的氧化应激具有生理相关性。）作为模型有机体。该海洋双壳类动物的标本经过实验暴露于镉（Cd），用作氧化应激诱导剂。分别在0、12、24、48、72和96 h评估g和消化腺中的Cd，金属硫蛋白（MT），谷胱甘肽（GSH），丙二醛（MDA）含量和谷胱甘肽还原酶（GR）活性。获得的结果提供了有关这项研究中考虑的非酶抗氧化剂细胞成分之间关系的新数据。这些构成了在受控实验室条件下暴露于Cd的蓝贻贝对氧化应激的迅速生理反应。