Here silver (GA-AgNPs) and gold nanoparticles (GA-AuNPs) were synthesized by an ecofriendly method using antioxidant, gallic acid (GA) simultaneously as capping and reducing agent. Their size ranged between 15 nm and 80 nm, which was controlled or dependent on the feeding ratio of GA. There was a linear relationship between the particle sizes versus the GA content. Moreover, they indicated a negative zeta potential value, which was decreased from −33 mV to −40 mV for AgNPs and from −36 mV to −42 mV for AuNPs after the addition of GA . In a typical PEGylation reaction of them, resulted into a large increase in the particle size as well as zeta potential value. The cytotoxicity assay against human fibroblast cell line (WI-38) for 24 h and 3-days showed that they were completely safe toward these cells. Therefore, these engineered NPs could be considered promising supplementary targeting materials in future.

在这里，银（GA-AgNPs）和金纳米颗粒（GA-AuNPs）是通过生态友好的方法合成的，同时使用抗氧化剂，没食子酸（GA）作为封端剂和还原剂。它们的尺寸在15nm至80nm之间，这是受控的或取决于GA的进料比。粒度与GA含量之间存在线性关系。此外，它们显示出负的ζ电势值，对于AgNPs，其从-33mV降至-40mV；对于AuNPs，其从-36mV降至-42mV。在它们的典型的PEG化反应中，导致粒径和ζ电势值大大增加。对人成纤维细胞系（WI-38）进行24小时和3天的细胞毒性试验表明，它们对这些细胞是完全安全的。因此，