Pt(II)-based metallacycles, as an important family of supramolecular coordination complexes (SCCs), have exhibited excellent antitumor activity at the cell level. However, the biomedical applications of Pt(II)-based metallacycles for animal studies are still hindered by their poor stability, non-targeted tumour, and lack of detectable feedback for evaluating therapeutic progress. Herein, we propose a strategy that introduces melanin dots as a biomedical platform to load bright-emission Pt(II)-based metallacycles, thereby constructing a theranostic agent that enables photoacoustic imaging (PAI)-guided chemo-photothermal combinational therapy. Melanin dots act as a protective carrier to preserve the integrity of Pt(II)-based metallacycles before uptake by tumour tissues. Meanwhile, the PAI signal from melanin dots furnishes more comprehensive information on the tumour. Moreover, the heat generated after NIR laser irradiation can not only trigger the apoptosis of tumour cells but also promote the deeper penetration of Pt(II)-based SCCs into tumour tissue, thus enhancing the efficiency of chemotherapy.

基于Pt（II）的金属环，作为超分子配位复合物（SCC）的重要家族，在细胞水平上表现出出色的抗肿瘤活性。但是，基于Pt（II）的金属环化合物在动物研究中的生物医学应用仍然受到其稳定性差，非靶向性肿瘤以及缺乏可评估的治疗进展反馈的阻碍。在这里，我们提出了一种策略，该策略引入黑色素点作为生物医学平台，以加载基于Pt（II）的亮发射金属环，从而构建了一种使光声成像（PAI）指导化学-光热联合治疗的治疗试剂。黑色素点充当保护性载体，以在肿瘤组织摄取之前保留基于Pt（II）的金属环的完整性。与此同时，黑色素点的PAI信号可提供有关肿瘤的更全面信息。此外，NIR激光照射后产生的热量不仅可以触发肿瘤细胞的凋亡，而且可以促进基于Pt（II）的SCC更深入地渗透到肿瘤组织中，从而提高化学疗法的效率。