Sevoflurane is widely used as an inhalational anesthetic in clinical practice. However, sevoflurane can cause cytotoxicity and induce learning capacity decline in patients. A previous publication indicated that miR-204-5p might have a close relationship with sevoflurane-induced neurotoxicity. When exposed to sevoflurane, the expression of miR-204-5p in neonatal hippocampus of rats was significantly increased. Hence, we aimed to investigate the role of miR-204-5p in sevoflurane-induced neurotoxicity using a mouse hippocampal neuronal cell line (HT22).

中文翻译：

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MicroRNA-204-5p 通过靶向脑源性神经营养因子介导 HT22 细胞中七氟醚诱导的细胞毒性。

七氟烷在临床实践中被广泛用作吸入麻醉剂。然而，七氟醚可引起细胞毒性并导致患者学习能力下降。之前的一篇文章表明 miR-204-5p 可能与七氟醚诱导的神经毒性有密切关系。暴露于七氟烷时，大鼠新生海马中miR-204-5p的表达显着增加。因此，我们旨在使用小鼠海马神经元细胞系 (HT22) 研究 miR-204-5p 在七氟醚诱导的神经毒性中的作用。