Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non-apoptosis. And cellular structure and molecules level changes also occur abnormally during ferroptosis. It has been proved that ferroptosis exist widespreadly in many diseases, such as heart disease, brain damage or alzheimer disease. At the same time, the role of ferroptosis in cancer cannot be underestimated. More and more indications have told that ferroptosis is becoming a powerful weapon against cancer. In addition, therapies rely on ferroptosis have been applied to the clinic. Therefore, it is necessary to understand this newly discovered form of cell death and its connection with cancer. This review summarizes the mechanism of ferroptosis, ferroptosis inducers based on different targets and inspection methods. At last, we analyzed the relationship between ferroptosis and malignancies, in order to provide a novel theory basis for cancer treatment.

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关于癌症治疗中铁死亡的新见解


铁死亡属于一种新型的受调节细胞死亡。其特点是铁依赖性、细胞内氧化还原平衡破坏和非凋亡。铁死亡过程中细胞结构和分子水平也会发生异常变化。现已证明，铁死亡广泛存在于多种疾病中，如心脏病、脑损伤或阿尔茨海默病等。同时，铁死亡在癌症中的作用也不容低估。越来越多的迹象表明，铁死亡正在成为对抗癌症的有力武器。此外，依赖铁死亡的疗法已应用于临床。因此，有必要了解这种新发现的细胞死亡形式及其与癌症的联系。本文根据不同靶点和检查方法，对铁死亡的机制、铁死亡诱导物进行综述。最后我们分析了铁死亡与恶性肿瘤的关系，以期为癌症治疗提供新的理论依据。