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Metal chelation reduces skin epithelial inflammation and rescues epithelial cells from toxicity due to thermal injury in a rat model
Burns & Trauma ( IF 6.3 ) Pub Date : 2020-10-02 , DOI: 10.1093/burnst/tkaa024
Amina El Ayadi 1 , Cheng Z Wang 2 , Min Zhang 2 , Michael Wetzel 1 , Anesh Prasai 1 , Celeste C Finnerty 1 , Perenlei Enkhbaatar 3 , David N Herndon 1 , Naseem H Ansari 2
Affiliation  

One of the most pervasive complications of burn injury is wound progression, characterized by continuous tissue destruction in untreated wounds, which leads to wound infection, inflammation, oxidative stress and excessive scar formation. We determined whether additional tissue destruction could be attenuated with Livionex formulation (LF) lotion, which contains a metal-chelating agent and reduces inflammation in burn wounds.

中文翻译:


金属螯合可减轻大鼠模型中的皮肤上皮炎症并挽救上皮细胞免受热损伤引起的毒性



烧伤最普遍的并发症之一是伤口进展,其特点是未经治疗的伤口持续组织破坏,导致伤口感染、炎症、氧化应激和过度疤痕形成。我们确定了 Livionex 配方 (LF) 洗剂是否可以减轻额外的组织破坏,该洗剂含有金属螯合剂,可减少烧伤创面的炎症。
更新日期:2020-10-02
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