Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is a recently discovered iron-dependent cell death pathway associated with the accumulation of lethal reactive lipid species. In the past few years, an increasing number of studies have suggested the crosstalk between autophagy and ferroptosis. Ischemic stroke is a complex brain disease regulated by several cell death pathways, including autophagy and ferroptosis. However, the potential links between autophagy and ferroptosis in ischemic stroke have not yet been explored. In this review, we briefly overview the mechanisms of ferroptosis and autophagy, as well as their possible connections in ischemic stroke. The elucidation of crosstalk between different cell death pathways may provide insight into new future ischemic stroke therapies.

自噬是一种通过降解有毒细胞内容物维持体内平衡的保守过程，可以促进细胞存活或加速细胞死亡。铁死亡是最近发现的一种铁依赖性细胞死亡途径，与致命活性脂质的积累相关。在过去的几年中，越来越多的研究表明自噬和铁死亡之间存在相互影响。缺血性中风是一种复杂的脑部疾病，受多种细胞死亡途径调节，包括自噬和铁死亡。然而，自噬与缺血性中风中铁死亡之间的潜在联系尚未被探索。在这篇综述中，我们简要概述了铁死亡和自噬的机制，以及它们在缺血性中风中可能的联系。阐明不同细胞死亡途径之间的串扰可能会为未来新的缺血性中风疗法提供见解。