Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for specific patient populations. In this review, we highlight changes in gastric cancer epidemiology with a special emphasis on racial and ethnic variations and discuss the implications of current clinical and preclinical treatment advances.

中文翻译：

---

胃癌的变化面貌：流行病学趋势和新疗法的进展

胃癌是一种侵袭性实体瘤恶性肿瘤，预后较差。胃癌的流行病学面貌正在发生变化，需要进一步了解其异质免疫组织病理学性质，以便为特定患者群体开发个性化治疗。在这篇综述中，我们强调了胃癌流行病学的变化，特别强调了种族和民族差异，并讨论了当前临床和临床前治疗进展的影响。