ABSTRACT

Skin and subcutaneous tissue tumors are the most common neoplasms in dogs. The most common sites of origin in dogs include digits, skin and the oral cavity including cheek and retromandibular area. We investigated canine squamous cell carcinoma (SCC) samples from 15 dogs and classified them histopathologically according to the degree of differentiation. bFGF, VEGF-C, TGF-β, PDGF-A, PDGF-C and PDGFR-α expressions were assessed using immunohistochemistry to determine the roles of growth factors during SCC. We found that TGF-β1 immunolabeling was elevated significantly compared to healthy controls in SCC originating from nailbeds, while expression of other growth factors did not change significantly. Our findings might explain the role of TGF-β1 in the infiltrative and malignant behavior of SCC originating from nailbeds.

摘要

皮肤和皮下组织肿瘤是狗最常见的肿瘤。狗最常见的起源部位包括手指、皮肤和口腔，包括脸颊和下颌后区域。我们调查了来自 15 只狗的犬鳞状细胞癌 (SCC) 样本，并根据分化程度对它们进行了组织病理学分类。使用免疫组织化学评估 bFGF、VEGF-C、TGF-β、PDGF-A、PDGF-C 和 PDGFR-α 的表达，以确定生长因子在 SCC 中的作用。我们发现，与健康对照组相比，源自甲床的 SCC 中 TGF-β1 免疫标记显着升高，而其他生长因子的表达没有显着变化。我们的研究结果可能解释了 TGF-β1 在源自甲床的 SCC 的浸润和恶性行为中的作用。