Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable long-term survival for patients diagnosed with many types of cancers. However, prognosis is poor for patients with metastasized disease. Melanoma is the deadliest form of skin cancer, yet in situ and localized, thin melanomas can be biopsied with little to no postsurgical follow-up. However, patients with metastatic melanoma require significant clinical involvement and have a 5-year survival of only 34% to 52%, largely dependent on the site of colonization. Melanoma metastasis is a multi-step process requiring dynamic changes in cell surface proteins regulating adhesiveness to the extracellular matrix (ECM), stroma, and other cancer cells in varied tumor microenvironments. Here we will highlight recent literature to underscore how cell adhesion molecules (CAM) contribute to melanoma disease progression and metastasis.

中文翻译：

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细胞粘附分子在可塑性和转移中的作用


在转移之前，现代疗法和手术干预可以为诊断患有多种癌症的患者提供有利的长期生存。然而，转移性疾病患者的预后较差。黑色素瘤是最致命的皮肤癌，但可以对原位和局部的薄黑色素瘤进行活检，几乎不需要术后随访。然而，转移性黑色素瘤患者需要大量的临床参与，并且 5 年生存率仅为 34% 至 52%，很大程度上取决于定植部位。黑色素瘤转移是一个多步骤的过程，需要细胞表面蛋白的动态变化来调节不同肿瘤微环境中细胞外基质 (ECM)、基质和其他癌细胞的粘附性。在这里，我们将重点介绍最近的文献，以强调细胞粘附分子 (CAM) 如何促进黑色素瘤疾病的进展和转移。