Integrins are transmembrane receptors that transduce biochemical and mechanical signals across the plasma membrane and promote cell adhesion and migration. In addition, integrin adhesion complexes are functionally and structurally linked to components of the intracellular trafficking machinery and accumulating data now reveal that they are key regulators of endocytosis and exocytosis in a variety of cell types. Here, we highlight recent insights into integrin control of intracellular trafficking in processes such as degranulation, mechanotransduction, cell–cell communication, antibody production, virus entry, Toll-like receptor signaling, autophagy, and phagocytosis, as well as the release and uptake of extracellular vesicles. We discuss the underlying molecular mechanisms and the implications for a range of pathophysiological contexts, including hemostasis, immunity, tissue repair, cancer, and viral infection.

整联蛋白是跨膜受体，可跨质膜转导生化和机械信号并促进细胞粘附和迁移。此外，整合素粘附复合物在功能上和结构上与细胞内运输机制的组成部分相关，并且越来越多的数据现在表明它们是多种细胞类型内吞作用和胞吐作用的关键调节剂。在这里，我们重点介绍了整合素在脱颗粒、机械转导、细胞间通讯、抗体产生、病毒进入、Toll 样受体信号传导、自噬和吞噬等过程中控制细胞内运输的最新见解，以及细胞外囊泡。我们讨论了潜在的分子机制和对一系列病理生理学背景的影响，