Abstract Design, research, and development of new and improved smart multifunctional devices is one of the main topics in the advanced functional materials agenda for the next decade. Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. The incorporation of magnetic nanostructures into complex systems produces multifunctional devices that can be spatiotemporally controlled by an external magnetic field. These magneto-responsive devices can be used for a multitude of biomedical applications, from diagnostic to the treatment of tumors, and are actively being developed and tested for cancer theranostics. Herein, we review the development of magneto-responsive devices for cancer theranostics, starting from the most straightforward architecture, single nanoparticles. We give some theoretical concepts about the design and production of such systems while providing a critical review of applications in clinical practice. Naturally, the review evolves to more complex architectures, from one-dimensional to three-dimensional magneto-responsive systems, demonstrating higher complexity and multifunctionality, and consequently, higher interest for clinical practice. The review ends with the main challenges in the design and engineering of magneto-responsive devices for cancer theranostics and future trends in this biomedical field.

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用于癌症治疗的磁响应装置的设计和工程：从纳米到宏观视角

摘要 新型和改进型智能多功能设备的设计、研究和开发是未来十年先进功能材料议程的主要课题之一。可以由外部刺激触发的智能材料被 FDA 和 EMA 等监管机构视为具有创新治疗和改进药物输送系统的巨大潜力。将磁性纳米结构结合到复杂系统中可以产生多功能设备，这些设备可以由外部磁场进行时空控制。这些磁响应设备可用于多种生物医学应用，从诊断到治疗肿瘤，并且正在积极开发和测试癌症治疗诊断。在此，我们回顾了用于癌症治疗诊断的磁响应设备的发展，从最简单的结构开始，单个纳米粒子。我们给出了有关此类系统的设计和生产的一些理论概念，同时对临床实践中的应用进行了批判性审查。自然地，该评论演变为更复杂的架构，从一维到三维磁响应系统，展示了更高的复杂性和多功能性，从而对临床实践产生了更高的兴趣。该评论以癌症治疗诊断磁响应设备的设计和工程中的主要挑战以及该生物医学领域的未来趋势结束。审查发展到更复杂的架构，从一维到三维磁响应系统，展示了更高的复杂性和多功能性，因此对临床实践的兴趣更高。该评论以癌症治疗诊断磁响应设备的设计和工程中的主要挑战以及该生物医学领域的未来趋势结束。审查发展到更复杂的架构，从一维到三维磁响应系统，展示了更高的复杂性和多功能性，因此对临床实践的兴趣更高。该评论以癌症治疗诊断磁响应设备的设计和工程中的主要挑战以及该生物医学领域的未来趋势结束。