Our aim was to investigate whether SARS-CoV-2 infection raised high risks of late pregnancy complications, and posed health problems in fetuses and neonates. We analyzed the data of COVID-19 pregnant women with COVID-19 during late pregnancy and their neonates. Eleven out of 16 (69%) pregnant women with COVID-19 had ++ or +++ of ketone body in urine. The blood uric acid of pregnant patients was 334 μmol/L (IQR, 269–452). D-dimer and FDP in pregnant patients were 3.32 mg/L (IQR, 2.18–4.21) and 9.6 mg/L (IQR, 5.9–12.4). Results of blood samples collected at birth showed that 16 neonates had leukocytes (15.7 × 10⁹/L (IQR, 13.7–17.2)), neutrophils (11.1 × 10⁹/L (IQR, 9.2–13.2)), CK (401 U/L (IQR, 382–647)), and LDH (445 U/L (IQR, 417–559)). Twenty-four hours after birth, a neonate from COVID-19 woman had fever and positive of SARS-CoV-2 gene. Another woman had strongly positive for SARS-CoV-2 gene (+++) for 4 weeks, and delivered one neonate who had SARS-CoV-2 IgM (46 AU/mL) and IgG (140 AU/mL) on day 1 after birth. In the third trimester, COVID-19 infection in pregnant patients raised high risks of ketonuria, hypercoagulable state, and hyperfibrinolysis, which may lead to severe complications. COVID-19 increased the inflammatory responses of placenta, and fetuses and neonates had potential organ dysregulation and coagulation disorders. There was a potential intrauterine transmission while pregnant women had high titer of SARS-CoV-2, but it is necessary to detect SARS-CoV-2 in the blood cord, placenta, and amniotic fluid to further confirm intrauterine infection of fetuses.

我们的目的是调查 SARS-CoV-2 感染是否会增加妊娠晚期并发症的高风险，并给胎儿和新生儿带来健康问题。我们分析了妊娠晚期感染 COVID-19 的 COVID-19 孕妇及其新生儿的数据。 16 名感染 COVID-19 的孕妇中有 11 名 (69%) 尿液中酮体含量为 ++ 或 +++。妊娠患者血尿酸为334μmol/L（IQR，269～452）。妊娠患者的 D-二聚体和 FDP 分别为 3.32 mg/L（IQR，2.18-4.21）和 9.6 mg/L（IQR，5.9-12.4）。出生时采集血样结果显示，16名新生儿的白细胞（15.7×10 ⁹ /L（IQR，13.7-17.2））、中性粒细胞（11.1×10 ⁹ /L（IQR，9.2-13.2））、CK（401 U） /L（IQR，382–647））和 LDH（445 U/L（IQR，417–559））。一名 COVID-19 妇女新生儿出生后 24 小时出现发烧症状，且 SARS-CoV-2 基因呈阳性。另一名妇女的 SARS-CoV-2 基因 (+++) 呈强阳性，持续 4 周，并在第一天生下一名新生儿，该新生儿具有 SARS-CoV-2 IgM (46 AU/mL) 和 IgG (140 AU/mL)出生后。在妊娠晚期，孕妇感染COVID-19会增加酮尿、高凝状态和纤溶亢进的高风险，从而可能导致严重的并发症。 COVID-19增加了胎盘的炎症反应，胎儿和新生儿存在潜在的器官失调和凝血障碍。孕妇SARS-CoV-2滴度较高时，存在潜在的宫内传播风险，但需要检测血脐带、胎盘、羊水中的SARS-CoV-2，以进一步确诊胎儿宫内感染。