Abstract

The CsMe/PVA/ZnO nanocomposite hydrogels have been introduced as a new object to deliver drugs, which is dependent on pH. They were prepared successfully in situ by forming of ZnO nanoparticles within swollen CsMe/PVA hydrogels. The resulting hydrogels were examined by running various experimental procedures such as FTIR, XRD, EDX and SEM. XRD and EDX patterns verified the formation of ZnO nanoparticles in the hydrogel networks; moreover, the formation of ZnO nanoparticles with size range from 34 to 88 nm within the hydrogel matrix was confirmed by SEM micrographs. It was shown that increased Zn²⁺ concentration led to increased number of Zn nanoparticles. The prepared nanocomposite hydrogels were studied in terms of the swelling behavior at the pH of 2.1 (simulated gastric fluid) and pH 7.4 (simulated intestinal fluid); the results showed that the prepared nanocomposite hydrogels outperformed the pure CsMe/PVA hydrogels in terms of swelling capacity. To study the efficiency of this new category of nanocomposite hydrogels drug release tests were conducted. For CsMe/PVA hydrogels containing ZnO nanoparticles sustained and controlled drug releases were observed that increased with increase in ZnO nanoparticles content which can lead to prolong the release of the drug.

中文翻译：

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基于羧甲基壳聚糖/聚乙烯醇/ ZnO纳米颗粒的pH敏感纳米复合水凝胶，具有药物输送特性

摘要

已经引入CsMe / PVA / ZnO纳米复合水凝胶作为递送药物的新对象，这取决于pH值。通过在溶胀的CsMe / PVA水凝胶中形成ZnO纳米颗粒，成功地就地制备了它们。通过运行各种实验程序（例如FTIR，XRD，EDX和SEM）检查所得的水凝胶。XRD和EDX图谱证实了水凝胶网络中ZnO纳米颗粒的形成；此外，通过SEM显微照片证实了在水凝胶基质内尺寸范围为34至88nm的ZnO纳米颗粒的形成。结果表明增加的Zn ²⁺浓度导致Zn纳米粒子数量增加。研究了制备的纳米复合水凝胶在pH 2.1（模拟胃液）和pH 7.4（模拟肠液）下的溶胀行为。结果表明，制备的纳米复合水凝胶的溶胀能力优于纯CsMe / PVA水凝胶。为了研究这种新型的纳米复合水凝胶的功效，进行了药物释放测试。对于含有ZnO纳米颗粒的CsMe / PVA水凝胶，观察到持续和受控的药物释放随ZnO纳米颗粒含量的增加而增加，这可以延长药物的释放。