Modern adhesives usually need to have integrated functions to meet the growing application needs, such as stimulus responsiveness, reversible adhesion ability, self-healing function, and adhesion ability under humid environments. Compared with traditional polymer adhesive materials, supramolecular adhesive materials made by self-assembly of small molecular monomers are rarely explored. Here, inspired by the conversion of thioctic acid (TA) from small molecular biological sources into high-performance supramolecular polymeric materials, catechol groups were grafted on thioctic acid and polyethylene glycol diacrylate (PEGDA) was introduced. TADP30 supramolecular adhesive material was successfully constructed. TADP30 achieves fast waterproof adhesion to a variety of substrates and is reusable. The self-healing ability comes from the dynamic disulfide bond between TADP30 molecules, which has high-efficiency self-healing ability (more than 80% tensile recovery within 1 hour). The benign structural unit of TADP30 makes it have low toxicity. In addition, a large number of catechol groups on the TADP chain endowed the adhesive with tissue adhesion properties and cell affinity. We expanded its biomedical applications by performing wound healing experiments with mouse liver injury models. The wound healing experiments proved that TADP30 has healing function and good in vivo compatibility. Compared with the control group, the total blood loss of the TADP30 adhesive group in the mouse liver injury model was reduced by nearly 70%. From multifunctional bonding to tissue healing and wound hemostasis, the polymer is expected to become a new type of adhesive material.

中文翻译：

---

基于小分子的超分子共聚物，用于多功能粘合剂和快​​速止血

现代粘合剂通常需要具有集成功能以满足不断增长的应用需求，例如刺激响应性，可逆粘合能力，自修复功能以及在潮湿环境下的粘合能力。与传统的聚合物粘合剂材料相比，很少探索通过小分子单体自组装制成的超分子粘合剂材料。在此，受硫酸（TA）从小分子生物学来源转化为高性能超分子聚合物材料的启发，将儿茶酚基团接枝到硫酸上，并引入了聚乙二醇二丙烯酸酯（PEGDA）。TADP30超分子粘合剂材料已成功构建。TADP30对各种基材具有快速的防水粘合性，并且可以重复使用。自修复能力来自TADP30分子之间的动态二硫键，具有高效的自修复能力（1小时内超过80％的拉伸回复率）。TADP30的良性结构单元使其毒性低。另外，TADP链上的大量邻苯二酚基团使粘合剂具有组织粘合特性和细胞亲和力。我们通过使用小鼠肝损伤模型进行伤口愈合实验来扩展其生物医学应用。伤口愈合实验证明TADP30具有愈合功能，并且具有良好的愈合作用。TADP链上的大量邻苯二酚基团使粘合剂具有组织粘合特性和细胞亲和力。我们通过使用小鼠肝损伤模型进行伤口愈合实验来扩展其生物医学应用。伤口愈合实验证明TADP30具有愈合功能，并且具有良好的愈合作用。TADP链上的大量邻苯二酚基团使粘合剂具有组织粘合特性和细胞亲和力。我们通过使用小鼠肝损伤模型进行伤口愈合实验来扩展其生物医学应用。伤口愈合实验证明TADP30具有愈合功能，并且具有良好的愈合作用。体内相容性。与对照组相比，TADP30胶粘剂组在小鼠肝损伤模型中的总失血量减少了近70％。从多功能粘合到组织愈合和伤口止血，该聚合物有望成为一种新型的粘合材料。