Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft.

中文翻译：

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α-8 整合素链 (itga8) 在肾脏肾小球稳态中的作用

肾小球肾炎导致肾小球细胞失调，最终可能导致慢性改变和随后的肾功能丧失。因此，了解有助于维持肾小球完整性的机制是治疗干预的关键先决条件。α-8 整合素链似乎是维持肾小球稳态的重要参与者，它为肾毛细血管簇提供机械稳定性和功能支持。