Construction and bioimaging application of novel indole heptamethine cyanines containing functionalized tetrahydropyridine rings,Journal of Materials Chemistry B

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Construction and bioimaging application of novel indole heptamethine cyanines containing functionalized tetrahydropyridine rings
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-10-01 , DOI: 10.1039/d0tb01890b
Xiaoxie Ma _{1,

2,

3,

4,

5} , Chen Zhang _{6,

7,

8,

9,

10} , Lan Feng _{1,

2,

3,

4,

5} , Sheng Hua Liu _{1,

2,

3,

4,

5} , Ying Tan _{6,

7,

8,

9,

10} , Jun Yin _{1,

2,

3,

4,

5}

Affiliation

IR780 as a commercially available dye with near-infrared emission has been extensively applied in fluorescent probes and bioimaging. In this work, to further intensify the optical behavior, a tetrahydropyridine ring was used to replace the cyclohexene ring at the center of IR780, forming a cyanine dye Cy-NH with near-infrared emission. Photophysical properties demonstrated that Cy-NH exhibits good optical performance. In particular, Cy-NH contains two functional reaction sites (e.g. Cl and NH sites on the tetrahydropyridine ring) and can be used to construct functional cyanine dyes. Investigation on imaging showed that these cyanines can be used as near-infrared fluorescent imaging agents in living cells and in vivo.

中文翻译：

新型含功能化四氢吡啶环的吲哚七甲胺花菁的构建及生物成像应用

IR780作为具有近红外发射的市售染料已广泛应用于荧光探针和生物成像。在这项工作中，为进一步增强光学性能，使用四氢吡啶环代替IR780中心的环己烯环，形成具有近红外发射的花青染料Cy-NH。光物理性质表明，Cy-NH具有良好的光学性能。特别地，Cy-NH包含两个功能性反应位点（例如，四氢吡啶环上的Cl和NH位点），并且可以用于构建功能性花菁染料。成像研究表明，这些花菁可用作活细胞和体内的近红外荧光成像剂。。

更新日期：2020-10-16

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