There are many large protein complexes involved in transcription in a chromatin context. However, recent studies on the SAGA coactivator complex are generating new paradigms for how the components of these complexes function, both independently and in concert. This review highlights the initial discovery of the canonical SAGA complex 23 years ago, our evolving understanding of its modular structure and the relevance of its modular nature for its coactivator function in gene regulation.

中文翻译：

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SAGA 染色质修饰复合物：部分之和大于整体

在染色质环境中，有许多大型蛋白质复合物参与转录。然而，最近对 SAGA 辅激活因子复合物的研究正在为这些复合物的成分如何独立和协同发挥作用产生新的范例。这篇综述重点介绍了 23 年前经典 SAGA 复合体的初步发现、我们对其模块化结构的不断理解以及其模块化性质与其在基因调控中的共激活因子功能的相关性。