Objective

The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA.

Design

In a case-control study, serum samples were collected from 84 patients with primary bilateral knee OA and 52 healthy controls. The radiographic grading of knee OA was performed using the Kellgren-Lawrence classification system. Serum concentrations of calprotectin were measured using an enzyme-linked immunosorbent assay.

Results

The mean serum calprotectin level was 2908 ± 2516 ng/mL in OA patients and 901 ± 875 ng/mL in healthy control subjects (P < 0.001). Mean serum calprotectin levels were significantly higher in the lower stages of OA: 3740 ± 2728 ng/mL in OA grade I, 3100 ± 2084 ng/mL in OA grade II, 2246 ± 1418 ng/mL in OA grade III, and 2035 ± 765 ng/mL in OA grade IV (P = 0.047). Serum calprotectin levels were significantly higher in patients with a disease duration <42 months compared with those with a disease duration >42 months (P = 0.043).

Conclusion

Serum calprotectin level increases significantly in the early stages of OA and shows a reverse association with disease severity. Therefore, it could be suggested as a promising blood-based marker for early-stage knee OA.

中文翻译：

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血清钙卫蛋白作为基于血液的生物标志物在早期但不是晚期监测膝关节骨性关节炎

客观的

早期骨关节炎 (OA) 的识别对于减缓其进展至关重要；然而，没有可靠的生物标志物可用于此目的。本研究旨在确定血清钙卫蛋白在检测早期膝关节 OA 中的作用。

设计

在一项病例对照研究中，从 84 名原发性双侧膝关节 OA 患者和 52 名健康对照者收集血清样本。使用 Kellgren-Lawrence 分类系统对膝关节 OA 进行影像学分级。使用酶联免疫吸附测定法测量血清钙卫蛋白浓度。

结果

OA 患者的平均血清钙卫蛋白水平为 2908 ± 2516 ng/mL，健康对照组为 901 ± 875 ng/mL ( P < 0.001)。在 OA 的较低阶段，平均血清钙卫蛋白水平显着升高：OA I 级为 3740 ± 2728 ng/mL，OA II 级为 3100 ± 2084 ng/mL，OA III 级为 2246 ± 1418 ng/mL，2035 ± OA IV 级为 765 ng/mL ( P = 0.047)。与病程>42 个月的患者相比，病程<42 个月的患者血清钙卫蛋白水平显着升高（P = 0.043）。

结论

在 OA 的早期阶段，血清钙卫蛋白水平显着增加，并显示出与疾病严重程度的反向关联。因此，它可以被建议作为早期膝关节 OA 的有前途的基于血液的标志物。