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Quantitative Determination of AZD3264, a Selective IkB-kinase IKK2 Inhibitor, in Dog Plasma by Solvent Induced Phase Transition Extraction Coupled with HPLC-MS/MS and its Application to Pharmacokinetic Study in Dogs
Journal of AOAC INTERNATIONAL ( IF 1.6 ) Pub Date : 2020-09-30 , DOI: 10.1093/jaoacint/qsaa134
Gang Li 1 , Shuofu Liang 2 , Kesen Qiao 1 , Chao Wang 1
Affiliation  

AZD3264 is a small molecule inhibitor of selective IkB-kinase IKK2 currently in preclinical development for the potential treatment of asthma and COPD.

中文翻译:

溶剂诱导相变萃取-HPLC-MS / MS定量测定狗血浆中选择性IkB激酶IKK2抑制剂AZD3264及其在犬体内药代动力学研究中的应用

AZD3264是选择性IkB激酶IKK2的小分子抑制剂,目前正处于临床前开发阶段,可用于治疗哮喘和COPD。
更新日期:2020-10-02
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