Coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2 infection has now evolved into a worldwide crisis that triggers substantial morbidity and mortality. COVID-19 occurs more frequently and has more serious complications in patients with diabetes mellitus, but the underlying mechanisms remain largely elusive. Here, we summarize current and evolving concepts on the detrimental effect of hyperglycemia on SARS-CoV-2 infection and consequences, focusing on several key mechanisms underlying the link between diabetes and COVID-19. A better understanding of the mechanisms by which hyperglycemia worsens the prognosis of COVID-19 is critical for reducing the risk of SARS-CoV-2 infection and its associated mortality.

中文翻译：

---

COVID-19与糖尿病：高血糖症的贡献

由冠状病毒SARS-CoV-2感染引起的冠状病毒疾病2019（COVID-19）现在已演变成一场全球性危机，引发大量发病和死亡。在糖尿病患者中，COVID-19的发生频率更高，并发症也更严重，但是其潜在机制仍然难以捉摸。在这里，我们总结了有关高血糖对SARS-CoV-2感染及其后果的有害影响的最新概念，重点放在糖尿病与COVID-19之间的联系的几种关键机制上。更好地了解高血糖会恶化COVID-19预后的机制对于降低SARS-CoV-2感染的风险及其相关死亡率至关重要。