Abstract

Sodium silicate with the formula of Na₂SiO₃ was used for the three-component reaction of ketones, aldehydes and cyanoacetamide. The effect of Zn₂SnO₄ nano-particles on the catalytic potential of Na₂SiO₃ was investigated. The desired products synthesized by this method are 5-amino-7-aryl-2,4-dioxo-2,3,4,4a,7,7a,8,9,10,11-decahydro-1H-benzo[i]quinazoline-6-carbonitriles, 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,9,10-decahydrocyclopenta[i]quinazoline-6-carbonitriles and 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydrothiopyrano[3,4-i]quinazoline-6-carbonitrile derivatives. This method has advantages of high yields, simple procedure, and easy work-up.

摘要

_{分子式为Na 2} SiO ₃的硅酸钠用于酮、醛和氰基乙酰胺的三组分反应。研究了Zn ₂ SnO ₄纳米粒子对Na ₂ SiO ₃催化电位的影响。通过该方法合成的所需产物为 5-amino-7-aryl-2,4-dioxo-2,3,4,4a,7,7a,8,9,10,11-decahydro-1 H -benzo [ i ]quinazoline-6-carbonitriles, 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,9,10-decahydrocyclopenta[ i ]quinazoline-6- carbonitriles和 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydrothiopyrano[3,4- i]喹唑啉-6-甲腈衍生物。该方法具有收率高、程序简单、后处理容易等优点。