ABSTRACT Due to the recent outbreak of COVID-19, the problem of protecting the individual against airborne transmission has become of great importance. This transmission occurs when virus-containing droplets enter the respiratory tract. Accordingly, the inactivation of airborne viruses plays significant role in mitigating the threat posed by a human-to-human infectious disease. The use of gas-based treatments such as ozone to decontaminate indoor air containing viruses has been increased. Ozone is a strong oxidizing agent that can be used to inactivate broad-range viruses that might be resistant to other disinfectants. The purpose of the study is to bring attention to the ozonizing of indoor air as a novel treatment for the inactivation of viruses. This review study showed that enveloped viruses (e.g., SARS-CoV-2) are more sensitive to oxidizing agents such as ozone than to non-enveloped viruses. Furthermore, some viruses such as coronaviruses have cysteine containing a sulfhydryl group that reacts with ozone gas. The study indicated that more free radicals will be formed when air humidity is higher, which could lead to higher virus inactivation. Air disinfection by ozone gas can be a promising approach for the viral deactivation of contaminated spaces in hospitals, health-care centers, dental offices, sport clubs, hotels and transportation sector, as well as all other places where viral disease outbreaks occur.

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臭氧气体对封闭空间空气传播病毒灭活的有效性：一项综述研究

摘要 由于最近爆发的 COVID-19，保护个人免受空气传播的问题变得非常重要。这种传播发生在含有病毒的飞沫进入呼吸道时。因此，空气传播病毒的灭活在减轻人与人传染病构成的威胁方面发挥着重要作用。越来越多地使用臭氧等基于气体的处理方法来净化含有病毒的室内空气。臭氧是一种强氧化剂，可用于灭活可能对其他消毒剂具有抗性的广谱病毒。该研究的目的是引起人们对室内空气臭氧化作为一种​​灭活病毒的新方法的关注。本综述研究表明，包膜病毒（例如，SARS-CoV-2）对臭氧等氧化剂比对无包膜病毒更敏感。此外，某些病毒（例如冠状病毒）的半胱氨酸含有与臭氧气体反应的巯基。研究表明，空气湿度越高，就会形成越多的自由基，从而导致病毒灭活率越高。臭氧气体对空气进行消毒可能是一种很有前景的方法，可用于对医院、保健中心、牙科诊所、体育俱乐部、酒店和交通部门以及所有其他发生病毒性疾病爆发的地方的受污染空间进行病毒灭活。研究表明，空气湿度越高，就会形成越多的自由基，从而导致病毒灭活率越高。臭氧气体对空气进行消毒可能是一种很有前景的方法，可用于对医院、保健中心、牙科诊所、体育俱乐部、酒店和交通部门以及所有其他发生病毒性疾病爆发的地方的受污染空间进行病毒灭活。研究表明，空气湿度越高，就会形成越多的自由基，从而导致病毒灭活率越高。臭氧气体对空气进行消毒可能是一种很有前景的方法，可用于对医院、保健中心、牙科诊所、体育俱乐部、酒店和交通部门以及所有其他发生病毒性疾病爆发的地方的受污染空间进行病毒灭活。