HLA-G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA-G function, polymorphism and pathology that have been confirmed by several different researchers, together with exposing aspects that may have been overlooked or not sufficiently remarked in this productive field of study. On the other hand, we question whether performing mainly studies on HLA-G and disease associations is going to give a clear answer in the future, since 40 years of study of classical HLA molecules association with disease has still given no definite answer on this issue.

中文翻译：

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HLA-G：功能、多态性和病理学

目前，许多研究小组正在研究 HLA-G 免疫调节基因和分子。在目前的研究中，我们的目标不是详尽无遗，因为每年出版的手稿数量是压倒性的。相反，我们的目标是指出一些不同研究人员已经证实的有关 HLA-G 功能、多态性和病理学的事实，同时揭示在这个富有成效的研究领域中可能被忽视或没有得到充分重视的方面。另一方面，我们质疑主要研究HLA-G和疾病关联是否会在未来给出明确的答案，因为经典HLA分子与疾病关联的研究40年在这个问题上仍然没有给出明确的答案。 .