Smooth muscle dysfunction in Duchenne muscular dystrophy (DMD) has been rarely studied. A cross‐sectional study was conducted to estimate the prevalence of smooth muscle dysfunction (vascular, upper gastrointestinal, and bladder smooth muscle) in children with DMD using questionnaires (Pediatric Bleeding Questionnaire, Pediatric Gastroesophageal Symptom Questionnaire, and Dysfunctional Voiding Symptom Score). Investigations included bleeding time estimation, nuclear scintigraphy for gastroesophageal reflux, and uroflowmetry for urodynamic abnormalities. Ninety‐nine subjects were included in the study. The prevalence of vascular, upper gastrointestinal, and bladder smooth muscle dysfunction was 27.2%. Mean bleeding time was prolonged by 117.5 seconds. The prevalence of gastroesophageal reflux was 21%. Voided volume/estimated bladder capacity over 15% and abnormal flow curves on uroflowmetry were seen in 18.2% and 9.7% of the subjects, respectively. Our study highlights the need for addressing issues related to smooth muscle dysfunction in the routine clinical care of patients with DMD.

中文翻译：

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小儿杜氏肌营养不良症患儿平滑肌功能障碍的患病率

很少研究杜兴肌营养不良症（DMD）中的平滑肌功能障碍。进行了一项横断面研究，以使用问卷（小儿出血问卷，小儿胃食管症状问卷和功能障碍性呕吐症状评分）来评估DMD儿童的平滑肌功能障碍（血管，上消化道和膀胱平滑肌）的患病率。研究包括出血时间估计，核闪烁显像术（用于胃食管反流）和尿流测定法（用于尿动力学异常）。该研究纳入了99名受试者。血管，上消化道和膀胱平滑肌功能障碍的患病率为27.2％。平均出血时间延长了117.5秒。胃食管反流的患病率为21％。分别在18.2％和9.7％的受试者中观察到超过15％的排尿体积/估计膀胱容量和尿流仪上的异常流量曲线。我们的研究强调在DMD患者的常规临床护理中需要解决与平滑肌功能障碍有关的问题。