Taking Different Roads: l‐Tryptophan as the Origin of Psilocybe Natural Products,ChemPlusChem

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Taking Different Roads: l‐Tryptophan as the Origin of Psilocybe Natural Products
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-10-01 , DOI: 10.1002/cplu.202000581
Claudius Lenz ₁ , Alexander Sherwood ₂ , Robert Kargbo ₂ , Dirk Hoffmeister ₁

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Psychotropic fungi of the genus Psilocybe, colloquially referred to as „magic mushrooms”, are best known for their l‐tryptophan‐derived major natural product, psilocybin. Yet, recent research has revealed a more diverse secondary metabolism that originates from this amino acid. In this minireview, the focus is laid on l‐tryptophan and the various Psilocybe natural products and their metabolic routes are highlighted. Psilocybin and its congeners, the heterogeneous blue‐colored psilocyl oligomers, alongside β‐carbolines and N,N‐dimethyl‐l‐tryptophan, are presented as well as current knowledge on their biosynthesis is provided. The multidisciplinary character of natural product research is demonstrated, and pharmacological, medicinal, ecological, biochemical, and evolutionary aspects are included.

中文翻译：

走不同的道路：l-色氨酸是拟杆菌天然产物的起源

Psilocybe属的精神真菌，俗称“魔术蘑菇”，以其l色氨酸衍生的主要天然产物psilocybin而闻名。然而，最近的研究表明，源自该氨基酸的次级代谢更加多样化。在这种minireview，重点是放在升色氨酸和各种裸盖菇天然产物及其代谢途径被突出显示。炭素胞素及其同源物，异质的蓝色psilocyl低聚物，以及β-咔啉和N，N-二甲基-l介绍了色氨酸，并提供了有关其生物合成的最新知识。证明了天然产物研究的多学科性，并且包括药理，医学，生态，生化和进化方面。

更新日期：2020-10-01

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