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N‐Heterocyclic Carbene Catalyzed Ester Synthesis from Organic Halides through Incorporation of Oxygen Atoms from Air
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-10-01 , DOI: 10.1002/anie.202011039
Ning Jiao 1 , Hui Tan 2 , Shen-An Wang 2 , Zixi Yan 2 , Jianzhong Liu 2 , Jialiang Wei 2 , Song Song 2
Affiliation  

Oxygenation reactions with molecular oxygen (O2) as the oxygen source provides a green and straightforward strategy for the construction of O‐containing compounds. Demonstrated here is a novel N‐heterocyclic carbene (NHC) catalyzed oxidative transformation of simple and readily available organic halides into valuable esters through the incorporation of O‐atoms from O2. Mechanistic studies prove that the deoxy Breslow intermediate generated in situ is oxidized to a Breslow intermediate for further transformation by this oxidative protocol. This method broadens the field of NHC catalysis and promotes oxygenation reactions with O2.

中文翻译:

通过结合空气中的氧原子从有机卤化物中合成N-杂环碳烯催化的酯

以分子氧(O 2)为氧源的加氧反应为构建含O化合物提供了绿色而直接的策略。这里展示的是一种新颖的N杂环卡宾(NHC)通过将O 2中的O原子并入,将简单易用的有机卤化物催化氧化转化为有价值的酯的方法。机理研究证明,原位产生的脱氧Breslow中间体被氧化为Breslow中间体,通过该氧化方案进一步转化。该方法拓宽了NHC催化领域,并促进了与O 2的氧化反应。
更新日期:2020-10-01
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