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Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging‐Guided Photothermal and Chemodynamic Therapy
Advanced Science ( IF 14.3 ) Pub Date : 2020-09-30 , DOI: 10.1002/advs.202000272
Yu Zhu 1 , Yingjie Wang 2 , Gareth R Williams 3 , Liyang Fu 1 , Jingjing Wu 1 , Hui Wang 1 , Ruizheng Liang 1 , Xisheng Weng 2 , Min Wei 1
Affiliation  

Transition metal dichalcogenides (TMDs) have received considerable attention due to their strong absorption in the near‐infrared (NIR) region, strong spin‐orbit coupling, and excellent photothermal conversion efficiency (PCE). Herein, CoFeMn dichalcogenide nanosheets (CFMS NSs) are prepared via facile vulcanization of a lamellar CoFeMn‐layered double hydroxide (LDH) precursor followed by polyvinyl pyrrolidone modification (to give CFMS‐PVP NSs), and found to show excellent photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT) performance. The as‐prepared CFMS‐PVP NSs inherit the ultrathin morphology of the CoFeMn‐LDH precursor and exhibit an outstanding photothermal performance with a η of 89.0%, the highest PCE reported to date for 2D TMD materials. Moreover, 50% of maximum catalytic activity (Michaelis–Menten constant, Km) is attained by CFMS‐PVP NSs with 0.26 × 10−3 m H2O2 at 318 K, markedly lower than the endogenous concentration of H2O2 inside tumor cells. In addition, complete apoptosis of HepG2 cancer cells and complete tumor elimination in vivo are observed after treatment with CFMS‐PVP NSs at a low dose, substantiating the NSs’ remarkable PTT/CDT efficacy. This work provides a new and facile approach for the synthesis of high‐quality multicomponent TMD nanosheets with precise process control, the potential for mass production, and outstanding performance, providing great promise in cancer theranostics.

中文翻译:

用于成像引导光热和化学动力学治疗的多组分过渡金属二硫属化物纳米片

过渡金属二硫化物(TMD)因其在近红外(NIR)区域的强吸收、强自旋轨道耦合和优异的光热转换效率(PCE)而受到广泛关注。在此,CoFeMn二硫属化物纳米片(CFMS NS)是通过层状CoFeMn层状双氢氧化物(LDH)前体的简单硫化制备的,然后进行聚乙烯吡咯烷酮改性(得到CFMS-PVP NS),并发现其表现出优异的光声(PA)成像和协同光热/化学动力学治疗(PTT/CDT)性能。所制备的CFMS-PVP NS继承了CoFeMn-LDH前驱体的超薄形貌,并表现出出色的光热性能,η89.0%,是迄今为止报道的二维TMD材料的最高PCE。此外, CFMS-PVP NSs 在 318 K 下使用 0.26 × 10 -3 m H 2 O 2达到了50% 的最大催化活性(Michaelis-Menten 常数,K m ) ,明显低于内源 H 2 O 2浓度肿瘤细胞内。此外,低剂量CFMS-PVP NSs治疗后观察到HepG2癌细胞完全凋亡,体内肿瘤完全消除,证实了NSs显着的PTT/CDT功效。这项工作为合成高质量多组分TMD纳米片提供了一种新的、简便的方法,具有精确的过程控制、大规模生产的潜力和出色的性能,为癌症治疗诊断提供了广阔的前景。
更新日期:2020-12-03
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