The effects of orally administered ovine serum immunoglobulin on dental plaque and associated oral immunity in cats were investigated. The two treatment groups consisted of 1) cats that were fed unsupplemented kibble (control diet) and 2) cats that were fed the same kibble but coated with a freeze-dried ovine serum immunoglobulin preparation (ovine Ig) (test diet). The adult cats were randomly allocated to one of the two diets (n = 15) and received their respective kibble for a 28-day experimental period. When compared to the ovine Ig-supplemented kibble, cats consuming the unsupplemented kibble had significantly (p < 0.05) higher dental plaque scores. Cat IgA and IgG concentrations in the saliva and serum were significantly (p < 0.05) higher for cats fed the unsupplemented kibble when compared to cats receiving the ovine Ig supplement. Similarly, myeloperoxidase activity in the saliva was significantly (p < 0.05) higher for cats fed the unsupplemented kibble when compared to cats receiving the Ig-supplement. Orally administered ovine serum Ig positively influenced oral health and oral immunity in cats as evidenced by preventing an increase of dental plaque formation, salivary and serum IgA and IgG concentrations and salivary myeloperoxidase activity.

研究了口服绵羊血清免疫球蛋白对猫牙菌斑和相关口腔免疫的影响。这两个治疗组由1）饲喂未补充粗粉的猫（对照饮食）和2）饲喂相同的粗粉但涂有冻干绵羊血清免疫球蛋白制剂（绵羊Ig）（测试饮食）的猫组成。将成年猫随机分配给两种饮食之一（n  = 15），并在28天的实验期内接受它们各自的粗磨。与添加绵羊Ig的粗磨食物相比，食用未添加粗磨的猫的 牙菌斑得分显着更高（p <0.05）。唾液和血清中的猫IgA和IgG浓度显着（p 与未接受绵羊Ig补充剂的猫相比，喂食未补充粗磨的猫要高出<0.05）。同样， 喂食未补充粗粉的猫的唾液中的髓过氧化物酶活性与接受Ig补充的猫相比，显着更高（p <0.05）。口服的绵羊血清Ig可以积极预防猫的口腔健康和口腔免疫，这可以通过预防牙菌斑形成，唾液和血清IgA和IgG浓度以及唾液髓过氧化物酶活性的增加来证明。