The combination of biomimetic scaffolds and nano drug delivery has been proposed to be an effective solution to the inherent limitations of the former in regulating cell behavior and bone tissue regeneration. Herein, a series of three-dimensional (3D) aspirin-loaded polylactic acid/graphene oxide (PLA/GO) porous biomimetic nanofibrous composite scaffolds (PBNCSs) was successfully prepared by phase separation. Results showed that the PLA/GO scaffolds have a biomimetic nanofibrous porous structure and a thin GO film covering the PLA nanofibers, which endows the latter with significantly improved hydrophilicity. Close interactions were noted in the GO–PLA interface. GO reduced the mechanical properties of the composite scaffolds but increased their thermal stability. The water absorption rate increased from 12.5% to 206.81% as the GO content increased from 0 to 5%. Addition of GO improved the deposition rate and amount of hydroxyapatite on the scaffolds. Overall, the PLA/GO PBNCSs demonstrated good cytocompatibility and sustained-release performance.

仿生支架和纳米药物递送的组合已被提出是对前者在调节细胞行为和骨组织再生中固有局限性的有效解决方案。本文中，通过相分离成功地制备了一系列三维（3D）阿司匹林负载的聚乳酸/氧化石墨烯（PLA / GO）多孔仿生纳米纤维复合支架（PBNCS）。结果表明，PLA / GO支架具有仿生纳米纤维多孔结构和覆盖PLA纳米纤维的薄GO膜，这使后者具有显着改善的亲水性。在GO–PLA界面中记录了紧密的交互。GO降低了复合支架的机械性能，但增加了其热稳定性。吸水率从12.5％增加到206。GO含量从0增加到5％时为81％。GO的添加改善了在支架上的沉积速率和羟基磷灰石的量。总体而言，PLA / GO PBNCS具有良好的细胞相容性和缓释性能。