Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets, leading to huge economic losses in the global swine industry. Vaccination remains the most promising and effective way to prevent and control PEDV. However, effective vaccines for PEDV are still under development. Understanding the genomic structure and function of PEDV and the influence of the viral components on innate immunity is essential for developing effective vaccines. In the current review, we systematically describe the recent developments in vaccine against PEDV and the roles of structural proteins, non-structural proteins and accessory proteins of PEDV in affecting viral virulence and regulating innate immunity, which will provide insight into the rational design of effective and safe vaccines for PEDV or other coronaviruses.

猪流行性腹泻病毒 (PEDV) 引起一种新发和再发的冠状病毒病，其特征是新生乳仔猪呕吐、急性腹泻、脱水和高达 100% 的死亡率，导致全球养猪业遭受巨大经济损失。疫苗接种仍然是预防和控制 PEDV 最有希望和最有效的方法。然而，针对 PEDV 的有效疫苗仍在开发中。了解 PEDV 的基因组结构和功能以及病毒成分对先天免疫的影响对于开发有效疫苗至关重要。在本综述中，我们系统地描述了 PEDV 疫苗的最新进展以及 PEDV 的结构蛋白、非结构蛋白和辅助蛋白在影响病毒毒力和调节先天免疫方面的作用，