In this paper, we propose the active delivery of multi-layer drug-loaded microneedle (MN) patches using a capsule that can be driven by an external magnetic field. Firstly, the multi-layer drug-loaded MN patches consist of three delivered MN patches which are composed of a drug-loaded MN patch and polydimethylsiloxane layer. The drug-loaded MN patch is made of a 10% gelatin solution and a drug. The multi-layer MN patches are attached to a permanent magnet in a magnetically driven capsule. Under an external magnetic field generated by an electromagnetic actuation system, the capsule with the multi-layer MN patches can reach the target lesions, and each MN patch can be delivered to the target lesions for medical treatment. The active delivery of the multi-layer MN patches using the proposed magnetically driven capsule was confirmed via phantom experiments. Accordingly, the adhesion of the three separated faces of the multi-layer MN patches and the adhesion between the porcine small intestine and the MN patch were measured using a load cell. We demonstrate the feasibility of the active delivery of the multi-layer MN patches to the target lesions on a porcine small intestine. Consequently, we expect that the active delivery of the multi-layer drug-loaded MN patches using the magnetically driven capsule presented in this study can be a useful method for drug delivery to lesions at various locations in the gastrointestinal tract.

在本文中，我们建议使用可由外部磁场驱动的胶囊主动递送多层载药微针 (MN) 贴片。首先，多层载药MN贴片由三个递送的MN贴片组成，由载药MN贴片和聚二甲基硅氧烷层组成。载药MN贴片由10%的明胶溶液和药物制成。多层 MN 贴片连接到磁驱动胶囊中的永磁体。在电磁驱动系统产生的外磁场作用下，带有多层MN贴片的胶囊可以到达目标病灶，每个MN贴片可以输送到目标病灶进行医疗。通过体模实验证实了使用所提出的磁驱动胶囊主动传递多层 MN 贴片。因此，使用称重传感器测量多层MN贴片的三个分离面的粘附以及猪小肠和MN贴片之间的粘附。我们证明了将多层 MN 贴片主动递送到猪小肠上的目标病变的可行性。因此，我们希望使用本研究中提出的磁驱动胶囊主动输送多层载药 MN 贴片可以成为将药物输送到胃肠道不同部位病变的有用方法。多层MN贴片的三个分离面的粘附力以及猪小肠与MN贴片之间的粘附力使用称重传感器测量。我们证明了将多层 MN 贴片主动递送到猪小肠上的目标病变的可行性。因此，我们希望使用本研究中提出的磁驱动胶囊主动输送多层载药 MN 贴片可以成为将药物输送到胃肠道不同部位病变的有用方法。多层MN贴片的三个分离面的粘附力以及猪小肠与MN贴片之间的粘附力使用称重传感器测量。我们证明了将多层 MN 贴片主动递送到猪小肠上的目标病变的可行性。因此，我们希望使用本研究中提出的磁驱动胶囊主动输送多层载药 MN 贴片可以成为将药物输送到胃肠道不同部位病变的有用方法。