Residue chemists who analyze pesticides in vegetables or veterinary drugs in animal-based food are currently facing a situation where there is a requirement to detect more and more compounds at lower and lower concentrations. Conventional tandem quadrupole instruments provide sufficient sensitivity, but speed and selectivity appear as future limitations. This will become an even larger issue when there is a need to not only detect active compounds but also their degradation products and metabolites. This will likely lead to a situation in which the conventional targeted approach must be expanded or augmented by a certain non-targeted strategy. High-resolution mass spectrometry provides such capabilities, but it frequently requires an additional degree of selectivity for the unequivocal confirmation of analytes present at trace levels in highly complex and variable food matrices. The hyphenation of ultrahigh performance liquid chromatography with ion mobility and high-resolution mass spectrometry provides analytical chemists with a new tool for performing such a demanding multiresidue analysis. The objective of this paper is to investigate the benefits of the added ion mobility dimension as well as to critically discuss the current limitations of this commercially available technology.

分析动物性食品中蔬菜或兽药中农药的残留化学家目前面临着这样一种情况，即需要检测越来越低浓度的越来越多化合物。传统的串联四极杆仪器具有足够的灵敏度，但速度和选择性似乎是未来的局限性。当不仅需要检测活性化合物而且需要检测其降解产物和代谢产物时，这将成为更大的问题。这可能会导致必须通过某种非针对性的策略来扩展或增强传统的针对性方法的情况。高分辨率质谱仪提供了这样的功能，但是，对于高度复杂和可变的食品基质中痕量水平的分析物的确凿确认，通常需要更高的选择性。具有离子迁移率和高分辨率质谱的超高效液相色谱联用为分析化学家提供了执行这种苛刻的多残留分析的新工具。本文的目的是研究增加的离子迁移率尺寸的好处，并严格讨论这种商用技术的当前局限性。