Fructose and uric acid as drivers of a hyperactive foraging response: A clue to behavioral disorders associated with impulsivity or mania?,Evolution and Human Behavior

当前位置： X-MOL 学术 › Evol. Hum. Behav. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fructose and uric acid as drivers of a hyperactive foraging response: A clue to behavioral disorders associated with impulsivity or mania?
Evolution and Human Behavior ( IF 3.0 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.evolhumbehav.2020.09.006
Richard J Johnson ₁ , William L Wilson ₂ , Sondra T Bland ₃ , Miguel A Lanaspa ₁

Affiliation

Abstract Several behavioral disorders, including attention deficit hyperactivity disorder (ADHD), bipolar disorder, and aggressive behaviors are linked with sugar intake and obesity. The reason(s) for this association has been unclear. Here we present a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup (HFCS), and uric acid (a fructose metabolite), in increasing the risk for these behavioral disorders. Recent studies have shown that the reason fructose intake is strongly associated with development of metabolic syndrome is that fructose intake activates an evolutionary-based survival pathway that stimulates foraging behavior and the storage of energy as fat. While modest intake may aid animals that would like to store fat as a protective response from food shortage or starvation, we propose that high intake of sugar and HFCS causes a hyperactive foraging response that stimulates craving, impulsivity, risk taking and aggression that increases the risk for ADHD, bipolar disease and aggressive behavior. High glycemic carbohydrates and salty foods may also contribute as they can be converted to fructose in the body. Some studies suggest uric acid produced during fructose metabolism may mediate some of these effects. Chronic stimulation of the pathway could lead to desensitization of hedonic responses and induce depression. In conclusion, a hyperactive foraging response driven by high glycemic carbohydrates and sugars may contribute to affective disorders.

中文翻译：

果糖和尿酸作为过度活跃觅食反应的驱动因素：与冲动或躁狂症相关的行为障碍的线索？

摘要几种行为障碍，包括注意力缺陷多动障碍 (ADHD)、双相情感障碍和攻击性行为与糖摄入和肥胖有关。这种关联的原因尚不清楚。在这里，我们提出了一个假设，支持果糖（糖和高果糖玉米糖浆 (HFCS) 的一种成分）和尿酸（果糖代谢物）在增加这些行为障碍的风险中的作用。最近的研究表明，果糖摄入与代谢综合征的发展密切相关的原因是果糖摄入激活了一种基于进化的生存途径，该途径刺激了觅食行为并将能量储存为脂肪。虽然适量摄入可能有助于动物储存脂肪作为食物短缺或饥饿的保护性反应，我们提出，高摄入糖和 HFCS 会导致过度活跃的觅食反应，刺激渴望、冲动、冒险和攻击性，从而增加多动症、双相情感障碍和攻击性行为的风险。高升糖碳水化合物和咸味食物也可能有所贡献，因为它们可以在体内转化为果糖。一些研究表明，果糖代谢过程中产生的尿酸可能会介导这些影响。该途径的慢性刺激可能导致享乐反应的脱敏并诱发抑郁。总之，由高血糖碳水化合物和糖类驱动的过度活跃的觅食反应可能导致情感障碍。双相情感障碍和攻击性行为。高升糖碳水化合物和咸味食物也可能有所贡献，因为它们可以在体内转化为果糖。一些研究表明，果糖代谢过程中产生的尿酸可能会介导这些影响。该途径的慢性刺激可能导致享乐反应的脱敏并诱发抑郁。总之，由高血糖碳水化合物和糖类驱动的过度活跃的觅食反应可能导致情感障碍。双相情感障碍和攻击性行为。高升糖碳水化合物和咸味食物也可能有所贡献，因为它们可以在体内转化为果糖。一些研究表明，果糖代谢过程中产生的尿酸可能会介导这些影响。该途径的慢性刺激可能导致享乐反应的脱敏并诱发抑郁。总之，由高血糖碳水化合物和糖类驱动的过度活跃的觅食反应可能导致情感障碍。

更新日期：2020-10-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11