OBJECTIVES To study the relationship between perceived fatigue and heath related quality of life (HRQoL), social support and cognition in an Argentinean population of patients with MS (PwMS). PATIENTS AND METHODS 128 PwMS were studied, 75 women (58 %). Mean age: 40 ± 10.49 years-old, education: 14 ± 3.04, Expanded Disability Status Scale (EDSS): 2.43 ± 1.87, evolution: 10.07 ± 7.23 years. INSTRUMENTS Fatigue Severity Scale (FSS); EDSS; Beck's Depression Inventory II (BDI-II); International Quality of Life questionnaire (MusiQoL); Medical Outcomes Study Social Support Survey (MOS); BICAMS Battery, 7/24 Spatial Recall Test, Paced Auditory Serial Task (PASAT-3), Word list generation task (WLG). RESULTS Sixty-six patients (51.6 %) presented fatigue. Significant differences were found between fatigued and non-fatigued patients in EDSS and BDI II (p < 0.001). Fatigue was associated with age, EDSS and BDI II (p < 0.05). When analyzing differences in HRQoL between fatigued and non-fatigued patients statistically significant differences were found in MusiQol (p < 0.05). FSS proved to be an independent predictor of HRQoL (typified β =-0.612 and -0.287, p < 0.05). Fatigued patients had fewer friends in their social support network (p = 0.031) and worse performance in PASAT. FSS was established as an independent predictor of PASAT (β = -0.280, p = 0.009) CONCLUSION: Fatigue is one of the most common symptoms in Multiple Sclerosis (MS) and has a great impact on patients daily life. This study highlights the importance of studying fatigue and treating it properly, since otherwise, it contributes to the dysfunction of patients daily life with psychological and social consequences.

中文翻译：

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多发性硬化症中的感知疲劳：强调其对生活质量、社交网络和认知的影响的重要性

目的 研究阿根廷 MS (PwMS) 患者人群中感知疲劳与健康相关生活质量 (HRQoL)、社会支持和认知之间的关系。患者和方法 研究了 128 名 PwMS，其中 75 名女性 (58 %)。平均年龄：40 ± 10.49 岁，教育：14 ± 3.04，扩展残疾状态量表 (EDSS)：2.43 ± 1.87，进化：10.07 ± 7.23 年。仪器疲劳严重程度量表 (FSS)；EDSS; 贝克抑郁量表 II (BDI-II)；国际生活质量问卷（MusiQoL）；医疗结果研究社会支持调查（MOS）；BICAMS 电池、7/24 空间回​​忆测试、节奏听觉串行任务 (PASAT-3)、单词列表生成任务 (WLG)。结果 66 名患者 (51.6 %) 出现疲劳。在 EDSS 和 BDI II 中发现疲劳和非疲劳患者之间存在显着差异（p < 0.001）。疲劳与年龄、EDSS 和 BDI II 相关（p < 0.05）。在分析疲劳和非疲劳患者之间 HRQoL 的差异时，在 MusiQol 中发现了统计学上的显着差异（p < 0.05）。FSS 被证明是 HRQoL 的独立预测因子（典型 β =-0.612 和 -0.287，p < 0.05）。疲劳的患者在他们的社会支持网络中的朋友较少（p = 0.031）并且在 PASAT 中的表现更差。FSS 被确立为 PASAT 的独立预测因子 (β = -0.280, p = 0.009) 结论：疲劳是多发性硬化症 (MS) 最常见的症状之一，对患者的日常生活有很大影响。这项研究强调了研究疲劳并正确对待它的重要性，否则，