Type 1 diabetes mellitus results from autoimmune destruction of pancreatic β cells. Insulin treatment is often inadequate in preventing devastating complications. Replacing β cells using stem cell-derived islets while fostering immune tolerance, exemplified in Yoshihara et al., holds the promise of a curative therapy for this disease.

中文翻译：

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解决1型糖尿病的β细胞替代疗法的免疫耐受难题

1型糖尿病是由胰腺β细胞自身免疫破坏引起的。胰岛素治疗通常不足以预防破坏性并发症。用干细胞衍生的胰岛替代β细胞，同时增强免疫耐受性，这在Yoshihara等人的研究中得到了证明，有望治愈该病。