Purpose

To determine the relationship between the maximum slope (MS) of ultrafast dynamic contrast-enhanced (DCE)-MRI and prognostic factors of breast cancer.

Methods

One hundred thirteen patients with 118 breast cancers were included in this study. The ultrafast DCE sequence was acquired using a higher parallel imaging factor. Its spatial resolution was 0.9 × 0.9 × 2.5 mm and its temporal resolution was 8.3 s/phase. Each lesion was automatically segmented, and the ROI of highest enhancement in the lesion was identified. In this ROI, the MS was calculated. The MS of each lesion was compared with various prognostic factors of breast cancer.

Results

The MS of invasive cancer (median: 9.81%/sec) was significantly higher than that of ductal carcinoma in situ (median: 7.26%/sec) (p = 0.001). In the ROC analysis, the area under the ROC curve (AUC) was 0.7295. The MS of invasive cancer with axillary lymph node (LN) metastasis (median: 11.97%/sec) was significantly higher than that without axillary LN metastasis (median: 9.425%/sec) (p = 0.0024). In the ROC analysis, the AUC was 0.7177. In addition, the MS became significantly higher as the level of the proliferation marker ki-67 increased (correlation coefficient: 0.3317) (p = 0.0009).

Conclusions

MS of ultrafast DCE-MRI is useful for predicting the prognostic factors of breast cancer.

Secondary abstract

Higher maximum slope (MS) is significantly associated with an invasive breast cancer component. Higher MS is significantly associated with an axillary lymph node metastasis. MS becomes significantly higher with increasing ki-67 (a proliferation marker). Ultrafast MRI is useful for predicting the prognostic factors of breast cancer.

中文翻译：

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乳腺超快动态对比增强MRI的最大斜率：与乳腺癌预后因素的比较

目的

确定超快动态对比增强（DCE）-MRI的最大斜率（MS）与乳腺癌的预后因素之间的关系。

方法

这项研究包括113例118例乳腺癌患者。超快DCE序列是使用更高的并行成像因子获得的。其空间分辨率为0.9×0.9×2.5 mm，时间分辨率为8.3 s /相。自动对每个病变进行分割，并确定病变中增强程度最高的ROI。在此ROI中，计算了MS。将每个病变的MS与乳腺癌的各种预后因素进行比较。

结果

浸润性癌的MS（中位数：9.81％/ sec）显着高于原位导管癌的MS（中位数：7.26％/ sec）（p  = 0.001）。在ROC分析中，ROC曲线下的面积（AUC）为0.7295。具有腋窝淋巴结转移的浸润性癌的MS（中位数：11.97％/秒）显着高于没有腋窝淋巴结转移的浸润癌的MS（中位数：9.425％/秒）（p  = 0.0024）。在ROC分析中，AUC为0.7177。此外，随着增殖标志物ki-67的水平升高，MS明显升高（相关系数：0.3317）（p  = 0.0009）。

结论

超快DCE-MRI的MS可用于预测乳腺癌的预后因素。

次要摘要

更高的最大斜率（MS）与浸润性乳腺癌成分显着相关。较高的MS与腋窝淋巴结转移明显相关。随着ki-67（增殖标记物）的增加，MS明显升高。超快MRI可用于预测乳腺癌的预后因素。