The desire for developing alternative natural pesticides/ repellents for pests causing crop loss, is growing each year, as the harmful effects of synthetic pesticides on humans and non-target species become established. Plants being the age-old source of various bioactive compounds, the insecticidal and repellency potential of Andrographis paniculata leaves was evaluated against adults of major stored-grain insect, Tribolium castaneum. Diet preference and dosage-mortality were the basis of assays to determine the repellency and insecticidal potential of the five solvent extracts i.e petroleum ether, ethyl acetate, acetone, 2-propanol, and water. Repellency assay was performed by evaluating the number of adult insects that preferred areas of localization between extract treated portion and control portion, on a filter paper disc. Statistical comparative analysis of averaged repellency and mortality rate was estimated with respect to increasing concentration (2.5%, 5%, and 10%) and duration of exposure (6 h interval). Our findings align with the facts that increase in the duration of exposure and concentration of solvent extracts increases the mortality of T. castaneum. The iso-propanolic extract showed complete repellency (within 12 h) and lethality (83%) on the insect and also significant activity was observed in the aqueous extract. The observed value of lethal dose (50%) for the iso-propanolic extract with 15 days of exposure was 26.6 mg/g and that of lethal time (LT₅₀) is eight days. The present study supported the occurrence of insect-specific antagonistic bioactive compounds in A. paniculata and depicted favored choice of solvents for the extraction of insecticidal constituents. It also underpins its potential as an alternative source of natural compounds for the management of stored grain pest.

随着合成农药对人类和非目标物种的有害影响的确立，对引起作物损失的害虫开发替代天然农药/驱虫剂的愿望每年都在增长。评估了作为各种生物活性化合物的古老来源的植物，对穿心莲的主要储粮昆虫Tribolium castaneum的成虫进行了杀虫和驱避作用评估。饮食偏好和剂量-死亡率分别为测定的基础上确定的五个溶剂提取物的排斥性和杀虫电位即石油醚，乙酸乙酯，丙酮，2-丙醇和水。通过评估滤纸盘上成虫的数量来进行拒斥性测定，成虫数量优选提取物处理部分和对照部分之间的定位区域。就浓度增加（2.5％，5％和10％）和暴露持续时间（6小时间隔）估计了平均排斥性和死亡率的统计比较分析。我们的发现与以下事实相吻合：增加暴露时间和溶剂提取物的浓度会增加锥叶锥虫的死亡率。。异丙醇提取物对昆虫表现出完全的驱避性（12小时内）和致死性（83％），在水提取物中也观察到了明显的活性。暴露15天的异丙醇提取物的致死剂量（50％）的观察值为26.6 mg / g，致死时间（LT ₅₀）的观察值为8天。本研究支持昆虫特异性拮抗生物活性化合物的发生穿心莲和描绘溶剂的偏爱选择杀虫成分的提取。它还巩固了其潜在潜力，可作为天然化合物的替代来源，用于管理储存的谷物害虫。