The COVID-19 pandemic has imposed urgency to answer numerous questions about the control of viral infections and the dual immune response of protection of and damage to the host, with the purpose of finding specific and efficient treatments and strategies for prevention of infection. The association between severe cases of the disease and overactivation of the immune response has raised the hypotheses that the inflammatory response participates in the pathogenesis of SARS-CoV-2 infection, and that neutrophils are important effector cells of such response. In this sense, neutrophils are potential targets for pharmacological interventions to treat this infection. The present paper briefly describes the neutrophil biology and discusses the possible roles that neutrophils play in the pathogenesis of COVID-19, based on literature data.

中文翻译：

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中性粒细胞和COVID-19：怎么回事？

COVID-19大流行已迫切需要回答许多有关控制病毒感染以及保护和损害宿主的双重免疫反应的问题，目的是找到预防感染的有效方法和策略。疾病的严重病例与免疫反应过度激活之间的关联提出了以下假设：炎症反应参与SARS-CoV-2感染的发病机理，中性粒细胞是此类反应的重要效应细胞。从这个意义上说，中性粒细胞是治疗这种感染的药理干预措施的潜在目标。本文根据文献资料简要描述了中性粒细胞生物学，并讨论了中性粒细胞在COVID-19发病机理中的可能作用。