Erectile dysfunction (ED) is a condition characterized by the inability to develop or maintain erection of the penis. Ayurveda recommends vanari gutika, prepared from Mucuna pruriens as one of the products suggested for the management of sexual dysfunction. We were interested to validate and compare aphrodisiac potential of vanari gutika formulated, as per the principles of Ayurveda, using milk obtained from jersey cow (Bos taurus), indigenous cow (Bos indicus) and buffalo (Bubalus bubalis). In order to assess the aphrodisiac activity, Swiss Albino mice were used as experimental subjects (n = 6 animals per group) with oral administration of aforesaid three formulations of vanari gutika with different doses i.e., 8.56 mg/mL, 17.14 mg/mL and compared with standard sildenafil citrate (5 mg/kg) and vehicle (milk+ghee) for 7 consecutive days.  Animals were observed for mating behavior. Hormonal analysis, sperm count and histopathological studies were carried out to confirm physiological changes. The study exhibit marked changes in sexual behavior. Vanari gutika formulated using milk from indigenous cow at higher dose (17.14 mg/mL) showed significant increase in mounting frequency, hormone levels, sperm count and histopathology which revealed the ruptured seminiferous tubules. These investigations confirmed significant intensification of sexual activities in experimental animals.

中文翻译：

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使用从泽西牛（Bos taurus），本土牛（Bos indicus）和水牛（Bubalus bubalis）获得的牛奶配制的vanari gutika的壮阳活性

勃起功能障碍（ED）是以无法发展或维持阴茎勃起为特征的疾病。阿育吠陀（Ayurveda）推荐从毛豆（Mucuna pruriens）制备的vanari gutika作为建议用于治疗性功能障碍的产品之一。我们有兴趣验证和比较根据阿育吠陀（Ayurveda）原理配制的瓦拉里古蒂卡（vanari gutika）壮阳药的潜力，使用从球衣奶牛（Bos taurus），土著奶牛（Bos indicus）和水牛（Bubalus bubalis）获得的牛奶）。为了评估壮阳活性，使用瑞士白化病小鼠作为实验对象（每组n只6只动物），口服上述三种不同剂量的瓦那利古塔卡制剂，即8.56 mg / mL，17.14 mg / mL并进行比较连续7天服用标准枸sil酸西地那非（5 mg / kg）和溶媒（牛奶+酥油）。观察动物的交配行为。进行激素分析，精子计数和组织病理学研究以确认生理变化。该研究表明性行为发生了明显变化。Vanari gutika使用较高剂量（17.14 mg / mL）的本地母牛奶配制而成，显示出坐骑频率，激素水平，精子数量和组织病理学显着增加，这显示出生精小管破裂。