Porphyrin structure carbon dots under red light irradiation for bacterial inactivation,New Journal of Chemistry

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Porphyrin structure carbon dots under red light irradiation for bacterial inactivation
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-09-30 , DOI: 10.1039/d0nj04013d
Ji Feng _{1,

2,

3,

4,

5} , Yong-Liang Yu _{1,

2,

3,

4,

5} , Jian-Hua Wang _{1,

2,

3,

4,

5}

Affiliation

Herein, novel carbon dots (CDs) with efficient antibacterial activity are prepared by a simple cyclization reaction of 4-formylbenzoic acid and pyrrole and cross-linking with p-phenylenediamine at room temperature. The CDs exhibit the fluorescence property of red emission, greatly reducing the noise interference from bacterial autofluorescence in fluorescence imaging. At the same time, the CDs with the feature of red absorption facilitate the achievement of light excitation of deep tissues in the living body. Owing to the introduction of the porphyrin ring structure as a photosensitizer, the CDs are able to trigger the generation of singlet oxygen. When excited by a 638 nm laser and irradiated for 20 min, 10 μg mL⁻¹ CDs can achieve complete bacterial extinction. Laser confocal microscopy imaging further demonstrates that the CDs act on the outside of bacteria and generate reactive oxygen species under red light irradiation, providing a non-multidrug resistant sterilization method.

中文翻译：

红光下的卟啉结构碳点用于细菌灭活

在此，通过4-甲酰基苯甲酸和吡咯的简单环化反应并在室温下与对苯二胺交联来制备具有有效抗菌活性的新型碳点（CD）。CD具有红色发射的荧光特性，大大减少了细菌自体荧光在荧光成像中的噪声干扰。同时，具有红色吸收特性的CD有助于实现活体内深层组织的光激发。由于引入了卟啉环结构作为光敏剂，因此CD能够触发单线态氧的产生。当由638 nm激光激发并照射20分钟时，为10μgmL ^-1CD可以实现细菌的完全灭绝。激光共聚焦显微镜成像进一步证明了CD可作用于细菌的外部，并在红光照射下产生活性氧，从而提供了一种非多药耐药的灭菌方法。

更新日期：2020-10-19

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